Cell-Free Tumor DNA (cf-tDNA) Liquid Biopsy: Current Methods and Use in Brain Tumor Immunotherapy
Wadden J, Ravi K, John V, Babila CM, Koschmann C.
Frontiers in Immunology, Apr 2022, Vol 13, Article 882452. doi:10.3389/fimmu.2022.882452
In plain English
Tiny fragments of tumor DNA float in spinal fluid and blood. This review surveys the methods for reading that DNA and shows how it can guide immunotherapy and help doctors avoid mistaking treatment-related healing for the tumor coming back.
For scientists
Gliomas cause significant morbidity and mortality, and development of precision diagnostics and novel targeted immunotherapies is critically important. This review examines cf-tDNA liquid biopsy methods and their application in brain tumor immunotherapy, addressing how circulating tumor DNA from CSF and plasma can resolve pseudoprogression and guide targeted therapies.